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KMID : 1013220200180020136
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Jouranl of the Korean Society of Clinical Toxicology
2020 Volume.18 No. 2 p.136 ~ p.140
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Initial Serum Ammonia as a Predictor of Mortality in Patients with Acute Glufosinate Ammonium Herbicide Poisoning
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Ko Eun-Na-Lae
Kim Dong-Hoon
Lee Soo-Hoon
Jeong Jin-Hee
Lee Sang-Bong
Sung Ae-Jin
Suh Ja-Hyoen
Kang Chang-Woo
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Abstract
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Purpose: The association of the initial serum ammonia level with in-hospital mortality in patients with acute glufosinate-ammonium herbicide poisoning was studied.
Methods: This retrospective cohort study was conducted between March 2012 and August 2019 in the emergency department after glufosinate-ammonium herbicide poisoning. Survivors and non-survivors were analyzed using a Mann-Whitney U test and Fisher’s exact test. Multivariate logistic regression analysis was performed to determine the independent risk factors for mortality.
Results: One hundred and six patients were enrolled; 11 died, yielding a mortality of 10.4%. The serum bicarbonate level was significantly lower in the non-survival group than the survival group. Age, serum ammonia, blood urea nitrogen, creatinine levels, SOFA score, and APACHE II score were significantly higher in the non-survival group than the survival group. Age, serum ammonia, and creatinine level were independent risk factors for mortality in multivariate logistic regression analysis.
Conclusion: The initial serum ammonia level is associated with mortality in patients with acute glufosinate herbicide poisoning.
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KEYWORD
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Glufosinate ammonium, Herbicide, Poisoning, Mortality
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